Vitamin B-12 (Cobalamin)

Vitamin B-12 (cobalamin) plays a role in making DNA and also helps keep nerve cells and red blood cells healthy.

Why do people take vitamin B-12?

Vitamin B-12 has been looked at as a treatment for many diseases and conditions. These include fatigue, Alzheimer’s disease, heart disease, breast cancer, high cholesterol, and sickle cell disease. However, the results have been inconclusive. Studies suggest that vitamin B-12 does not help with stroke risk or lung cancer.

Vitamin B-12 supplements do help people who have a deficiency. Low levels of vitamin B-12 are more likely in people over age 50. Vitamin B-12 is also more common in those with certain conditions, like digestive problems and some types of anemia. Low vitamin B-12 can cause fatigue, weakness, memory loss, and other problems with the nervous system.

There is some conflicting evidence about using vitamin B-12 to treat elevated levels of homocysteine in the blood. It is not fully understood how or if this elevation contributes to heart disease and other problems with blood vessels, or if the elevation is a result of these conditions. A high level of homocysteine in the blood is a risk factor for coronary, cerebral, and peripheral blood vessel disease. Risks also include blood clots, heart attacks, and certain types of stroke. However, recent guidelines do not recommend general screening for or treating elevated homocysteine levels unless there is suspicion of homocystinuria. That’s a genetic condition that affects the body’s ability to break down certain proteins. Instead of trying to treat yourself for elevated levels of homocysteine, it is important that you talk with your doctor about your concerns.

A recent study showed that vitamin B-12, used with folic acid and vitamin B6, reduces the risk for age-related macular degeneration (AMD) in women with heart disease or multiple risk factors for heart disease.

How much vitamin B-12 should you take?

The recommended dietary allowance (RDA) includes the vitamin B-12 you get from both food and any supplements you take.

Even at high doses, vitamin B-12 seems fairly safe. Experts have not found a specific dose of vitamin B-12 that’s dangerous. No tolerable upper intake levels have been set.

Can you get vitamin B-12 naturally from foods?

Some good food sources of vitamin B-12 are:

  • Fish and shellfish
  • Meats
  • Poultry and eggs
  • Dairy products
  • Fortified cereals

Generally, it’s best to get vitamins from whole foods. But doctors often suggest fortified foods — and supplements — to people over age 50. As we age, it’s harder for our bodies to absorb vitamin B-12 from food.

What are the risks of taking vitamin B-12?

Side effects and risks. Taken at normal doses, side effects are rare. High doses may cause acne. Allergies to vitamin B-12 supplements have been reported and can cause swelling, itchy skin, and shock.
Interactions. Drugs for acid reflux, diabetes, and other conditions may make it harder for your body to absorb vitamin B-12.


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